The Broad Developmental and Clinical Landscape of Congenital Heart Disease Represented by Tetralogy of Fallot
Congenital heart disease (CHD) affects 1 in 100 children globally and while great progress has been made in our understanding of the developmental mechanisms and in treatments for CHD there are continuing challenges and opportunities. This talk will provide an overview of the broad landscape of CHD including perspectives on the dramatic advances in surgical management of CHD from the first operation in 1944 to present day; the spectacular progress made in identifying developmental mechanisms of CHD from the first NIH grant on this topic in 1986; highlight some insights from the investigation of developmental cardiovascular biomechanics; discuss some of the progress made in supporting the failing heart including mechanical assist devices and stem cell therapies; and then provide some comments on current needs and opportunities. This talk will be of interest to medical, biomedical, and bioengineering students and investigators.
Bio: Dr. Bradley Keller is internationally recognized for his novel research in defining the biomechanical forces that regulate normal and abnormal heart formation, for developing engineered tissues that can be used for cardiac repair and regeneration, and the development and testing of innovative technologies including home telemedicine solutions.
Dr. Keller received his first NIH funded award in 1988, has received funding from the AHA, and has participated in the successful funding of over $30M related to pediatric cardiovascular research. He has served as a mentor for undergraduate and graduate medical and bioengineering students, and for medical students, residents, and fellows from the United States, Japan, and China. He has served as a peer reviewer for multiple NIH study sections in the areas of cardiovascular developmental biology, stem cells, tissue engineering, and novel cardiovascular technologies and continues to serve as a peer reviewer for numerous academic publications.
Dr. Keller earned his B.S. from the University of Pennsylvania in 1981 and his M.D. from The Pennsylvania State University School of Medicine in Hershey in 1985. He completed his in pediatrics at Johns Hopkins Hospital in 1988 and his fellowship in pediatric cardiology at the University of Rochester Medical Center in 1991.